Purpura fulminans in a child with combined heterozygous prothrombin G20210A and factor V Leiden mutations
Annals of Hematology, cilt.82, sa.2, ss.118-120, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 82 Sayı: 2
- Basım Tarihi: 2003
- Doi Numarası: 10.1007/s00277-003-0613-5
- Dergi Adı: Annals of Hematology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.118-120
- Anahtar Kelimeler: purpura fulminans, heterozygous prothrombin G20210A mutation heterozygous factor V Leiden
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Although thrombosis is relatively rare in children, reports of young patients with thrombosis are becoming more frequent with time. Activated protein C resistance and prothrombin 20210 A mutation are results of point mutations described in the last decade. This article highlights a case of a child with severe arterial thrombosis who was heterozygous for the factor V Leiden (FVL) and prothrombin G20210A mutations. The patient diagnosed with purpura fulminans was an 8-year-old boy who was referred to our hospital with purpuric lesions on the extremities and necrosis of the penis. We believe that the coexistence of more than one thrombophilic mutation contributed to the occurrence of severe thrombosis at a young age in this patient.