The predictive value of mean platelet volume in differential diagnosis of non-functional pancreatic neuroendocrine tumors from pancreatic adenocarcinomas
European Journal of Internal Medicine, cilt.22, sa.6, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 6
- Basım Tarihi: 2011
- Doi Numarası: 10.1016/j.ejim.2011.04.005
- Dergi Adı: European Journal of Internal Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Pancreas adenocarcinoma, Neuroendocrine tumor, Mean platelet volume, CA19-9
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The aim of the present study is to evaluate in a retrospective manner the diagnostic value of mean platelet volume (MPV) in pancreatic adenocarcinomas and pancreatic neuroendocrine tumors (PNETs). Patients and methods: A total of 92 patients, who were admitted for pancreatic adenocarcinoma (n = 76) and PNET (n = 16) between March 2007 and December 2009, were analyzed retrospectively for demographics and clinical information. Results: Thirty-nine patients (51.3%) had a resectable, whereas 37 patients (48.7%) had an unresectable pancreatic adenocarcinoma. Nine patients (56.3%) had a non-functional PNET, 6 patients (37.5%) had an insulinoma, and the remaining one patient had a gastrinoma. The mean age was 59.3 ± 10.5 for pancreatic adenocarcinomas and 45.1 ± 10.6 for PNETs. The mean age at diagnosis was significantly higher in patients with pancreatic adenocarcinomas than the patients with PNET (p < 0.001). Preoperative mean hemoglobin levels were significantly lower in patients with pancreatic adenocarcinoma than those with PNET (12.4 ± 1.8 g/dl vs 13.7 ± 2.2 g/dl), (p < 0.013). The preoperative median MPV levels were significantly lower in patients with PNET 7.8 fL (7.2-9.4) than in patients with pancreatic adenocarcinomas 8.6 fL (6.6-13.5), (p < 0.014). In subgroup analysis, a significant difference in MPV levels was mainly caused by the difference between pancreatic adenocarcinomas and non-functional PNETs (p = 0.017). The cut-off value of MPV level for detection of PNETs was calculated as ≤ 7.8 fL using ROC analysis [Sensitivity: 66.7%, specificity: 75.9%, AUC: 0.734 (0.587-0.880) p = 0.022]. In logistic regression analysis, independent predictive factors for determining PNETs in the differential diagnosis of pancreatic adenocarcinomas were calculated as age (OR = 0.068, 95% CI: 0.012-0.398), Ca 19-9 (OR = 0.039, 95% CI: 0.006-0.263), MPV (OR = 0.595, 95% CI: 0.243-1.458), and hemoglobin (OR = 1.317, 95% CI: 0.831-2.086). Conclusion: Age, Ca 19-9, MPV, and hemoglobin levels have diagnostic value for distinguishing PNETs from pancreatic adenocarcinomas. © 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.