Can serum vaspin levels predict clomiphene resistance in infertile women with PCOS?

DOĞAN K., Ekin M., Helvacioğlu Ç., YAŞAR L.

European Journal of Obstetrics and Gynecology and Reproductive Biology, cilt.217, ss.6-11, 2017 (SCI-Expanded, Scopus)

Özet

Objective To determine whether serum vaspin levels can predict the success of ovulation induction and clomiphene resistance in anovulatory women with PCOS. Study design We designed a prospective case control study. The study population (n = 49) was composed of infertile women with PCOS who underwent ovulation induction with clomiphene citrate. Patients were divided into two groups based on their treatment response. Group I consisted of patients with failed ovulation induction, and group II consisted of patients with successful ovulation induction. The study group characteristics, including age, BMI, waist-to-hip ratio, parity, hormone profiles, fasting insulin and glucose levels, HOMA-IR, triglycerides, and cholesterol and serum vaspin levels, were compared between the study groups. Result(s) There were 29 patients in Group I with failed ovulation induction (59.2%), and Group II consisted of 20 patients with successful ovulation induction (40.8%). No differences in characteristics were found. However, serum vaspin levels were significantly lower in responders achieving ovulation (p = 0.001; p < 0.01). At a vaspin level of 3.74, the sensitivity, specificity, positive predictive and negative predictive values were 90%, 72.4%, 69.2% and 91.3%, respectively. The odds ratio was determined to be 14.87 (95% CI: 3.41–64.88) as the cut-off point. No significant correlation was found in serum vaspin measurements between pregnant and non-pregnant patients who had achieved successful ovulation induction (p = 0.5). Conclusion(s) Serum vaspin level may be a useful marker for the prediction of ovulation induction success in treatment with clomiphene citrate, and increased vaspin levels (≥3.74 ng/mL) are correlated with clomiphene resistance in patients with PCOS according to our study results.