Tumor necrosis factor-α and interleukin-1β levels in recurrent and persistent otitis media with effusion
Otolaryngology - Head and Neck Surgery, cilt.126, sa.4, ss.417-422, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 126 Sayı: 4
- Basım Tarihi: 2002
- Doi Numarası: 10.1067/mhn.2002.124188
- Dergi Adı: Otolaryngology - Head and Neck Surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.417-422
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
OBJECTIVE: Based on interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels in effusions, our goals were to specify either recurrent or persistent otitis media with effusion (OME) is a mid stage in the development of chronic disease and to identify the factors that have an influence on cytokine levels. STUDY DESIGN: Samples from groups with recurrent (n = 15) and persistent (n = 39) OME were essayed for IL-1β and TNF-α. Children were also grouped with respect to age, sex, quality of effusion, and the presence of pharyngeal adenoid tissue. SETTING: Tertiary referral center. RESULTS: In recurrent and persistent OME groups, IL-1β was higher than TNF-α (P < 0.01). IL-β was higher in recurrent OME than in persistent OME (P < 0.05). CONCLUSION: Recurrent OME seems to be closer to the chronic stage of the disease relative to persistent OME in terms of higher IL-1β levels. Each exacerbation of acute disease in recurrent ofitis media is likely to be mediated by IL-1β. SIGNIFICANCE: We were able to clarify that recurrent OME is a stage that occurs before chronic OME. Therefore, the prevention of acute attacks in recurrent disease would also impede long-term damage to the middle ear. Copyright © 2002 by the American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc.