Could 25-oh Vitamin D deficiency be a reason for hpv infection persistence in cervical premalignant lesions?
Journal of Experimental Therapeutics and Oncology, cilt.11, sa.3, ss.177-180, 2016 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 11 Sayı: 3
- Basım Tarihi: 2016
- Dergi Adı: Journal of Experimental Therapeutics and Oncology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.177-180
- Anahtar Kelimeler: Cervical intraepithelial lesions, Cholecalciferol, HPV, Vitamin D
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Vitamin D is an essential precursor to the steroid hormone calcitriol which mainly regulates calcium homeostasis. Moreover anti-proliferative, proapoptotic, anti-angiogenic effects of Vitamin D support the ideas of preventive role in various cancer. This study aimed to determine if there is a relationship between HPVDNA infection and cervical intraepithelial neoplasia and Vitamin D deficiency. As a result of the study the difference of 25-OH Vitamin D3 levels between HPVDNA positive group and the control group were statistically significant (p=0,009). According to results of our study, with the proven anti-inflammatory functions of Vitamin D, the deficiency of these molecule and its metabolites can be a possible reason for HPVDNA persistence and related cervical intraepithelial neoplasia.