Plasma human neutrophil proteins-1, -2, and -3 levels in patients with bladder cancer
Journal of Cancer Research and Clinical Oncology, cilt.139, sa.2, ss.195-199, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 139 Sayı: 2
- Basım Tarihi: 2013
- Doi Numarası: 10.1007/s00432-012-1305-0
- Dergi Adı: Journal of Cancer Research and Clinical Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.195-199
- Anahtar Kelimeler: Bladder cancer, Clinicopathological parameters, Human neutrophil proteins-1,-2, and-3
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Objectives: Human neutrophil proteins-1, -2, and -3 (HNPs -1, -2, and -3) are expressed in several tumor types. However, the role of HNPs 1-3 in human bladder cancer has not yet been determined. We investigated the association between the plasma levels of HNPs 1-3 and clinicopathological parameters in bladder cancer patients. Design and methods: The plasma levels of HNPs 1-3 were measured in 60 patients with bladder cancer and in 58 healthy controls. The plasma levels of HNPs 1-3 were determined by a solid-phase enzyme-linked immunosorbent assay (ELISA). Plasma samples were obtained before surgery. Plasma samples were permitted to clot and were then stored at -80 C until use. Results: The levels of the HNPs increased from grade 1 to 4 tumors and this difference was statistically significant (p < 0.001). Additionally, plasma HNP levels were significantly higher in patients with metastatic bladder cancer and in patients with lymphovascular involvement, metastasis of the lymph nodes, and increased tumor burden (p < 0.001). Conclusions: The preoperative plasma levels of HNPs 1-3 paralleled the progression and pathological stages of the malignancies. This study suggests that HNPs 1-3 promote tumor invasion and are potential indicators of disease progression in patients with bladder cancer. © 2012 Springer-Verlag Berlin Heidelberg.