Mid-term clinical and echocardiographic evaluation of super responders with and without pacing: The preliminary results of a prospective, randomized, single-centre study
Europace, cilt.18, sa.6, ss.842-850, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 6
- Basım Tarihi: 2016
- Doi Numarası: 10.1093/europace/euv129
- Dergi Adı: Europace
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.842-850
- Anahtar Kelimeler: Cardiac resynchronization therapy, Deactivation, Outcome, Super response
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aims Super response to cardiac resynchronization therapy (CRT) is related to excellent long-term prognosis. However, it is not known whether super responders (SRs) are in remission or have made a complete recovery. In other words, is CRT a destination therapy or a bridge to recovery? The objectivewas to assess the evolution of the clinical and echocardiographic data of SRs without pacemaker activity at the mid-term follow-up. Methods and results A total of 19 SRs were randomly assigned to a deactivated pacemaker function (Off-Pace group) or a continued pacemaker activity (On-Pace group). Clinical and echocardiographic parameters were evaluated before implantation, at randomization, and after 6 and 12 months of this randomization. Patients assigned to the Off-Pace group deteriorated in terms of the New York Heart Association class (from 1.3±0.5 to 2.4±0.7), 6-min walk distance (from 569±68 to 343±162 m), and echocardiographic data, including left ventricular ejection fraction (from 55±3 to 36±12%), left ventricular end-systolic volume (from 61±10 to 117±36 mL), left ventricular end-diastolic diameter (from 53±3 to 61±6 mm), and left ventricular end-systolic diameter (from 40±3 to 53±8 mm) at 12 months, whereas no change was observed in the On-Pace group. Turning off the pacemaker function was also related to hospitalization for heart failure and appropriate cardioverter-defibrillator device intervention. Conclusion Super responders without pacing had poor clinical and echocardiographic outcomes at the mid-term follow-up. Published on behalf of the European Society of Cardiology. All rights reserved.