Complete blood count-derived inflammatory indices: A noninvasive aid for risk stratification in gastric ulcer
World Journal of Gastroenterology, cilt.32, sa.5, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 5
- Basım Tarihi: 2026
- Doi Numarası: 10.3748/wjg.v32.i5.114497
- Dergi Adı: World Journal of Gastroenterology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Anahtar Kelimeler: Gastric ulcer, Systemic inflammation, Complete blood count, Inflammatory biomarkers, Systemic inflammatory response index, Risk stratification
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Gastric ulcer (GU) remains a significant global health concern, often leading to severe complications such as bleeding and perforation. While Helicobacter pylori infection and nonsteroidal anti-inflammatory drug use are well-recognized etiological factors, systemic inflammation plays a pivotal but underexplored role in GU pathogenesis. Shen et al provide compelling evidence linking complete blood count-derived inflammatory biomarkers with GU prevalence, identifying the systemic inflammatory response index as the most discriminative marker. Their cross-sectional analysis underscores the potential of routine hematological parameters as cost-effective, accessible tools for early identification of high-risk individuals. Importantly, this study adds to the growing body of literature suggesting that simple indices - neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and systemic inflammatory response index - may serve not only as diagnostic aids but also as windows into disease mechanisms involving im-mune dysregulation and oxidative stress. Future prospective and mechanistic stu-dies are warranted to determine whether these markers can predict ulcer re-currence, guide therapeutic interventions, or integrate into precision gastroente-rology. By leveraging widely available blood tests, we may move closer to a pa-radigm where inexpensive inflammatory indices refine GU risk stratification and management strategies.