The comparison of vitamin d levels of healthy and gestational diabetic pregnant women Sağlikli ve gestasyonel dıabetes mellıtuslu gebelerın d vıtamını sevıyelerının karşilaştirilmasi
Journal of Clinical and Analytical Medicine, cilt.8, sa.4, ss.275-279, 2017 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.4328/jcam.4852
- Dergi Adı: Journal of Clinical and Analytical Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.275-279
- Anahtar Kelimeler: Gestational Diabetes Mellitus, Pregnancy, Vitamin D Status
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: To evaluate and compare 25-hydroxyvitamin D [25(OH)D3] levels of women with gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT). Material and Method: A total of 40 women (20 with GDM and 20 with NGT) admitted to the clinic of obstetrics and gynecology due to follow-ups between the 24th and 28th gestational weeks and exposed to 50 and/or 100 gr oral glucose tolerance testing (OGTT) were enrolled into this prospective case-controlled study. Patients with GDM and controls with NGT were defined according to the 2013 criteria of the American College of Obstetricians and Gynecologists (ACOG). Age, height, weight, body mass index (BMI), history of previous diseases and surgeries, vitamin D replacement, clothing style (in this region 95% of participants dress in a style that prevents the sun from reaching skin) exercising status, and familial history were recorded. Serum samples were collected between the 24th and 28th gestational weeks to measure 25(OH)D3 levels via the chemiluminescence method. Results: Mean 25(OH)D3 levels were found as 8.71±3.36 ng/mL (ranging from 4.20 to 18.84). Vitamin D deficiency (<10 ng/mL) and insuffi-ciency(10-30 ng/ml) were observed at the rate of 70% and 30%, respectively. 25(OH)D3 levels were 9.40±3.53ng/mL in patients with GDM and 8.0±3.11 ng/mL in controls with NGT. In terms of vitamin D deficiency, no statistically significant difference was found between the GDM and NGT groups. Discussion: 25(OH)D3 levels were found to be similar or lower in patients with GDM and those with NGT. We consider that prospective, randomized-controlled and comprehensive studies with larger populations are needed to illuminate the role of 25(OH)D3 levels in the development of GDM.