Liver stiffness and serum galectin 3 level significantly increases in patients with prediabetes: a fibroscan study
PeerJ, cilt.13, sa.4, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 13 Sayı: 4
- Basım Tarihi: 2025
- Doi Numarası: 10.7717/peerj.19377
- Dergi Adı: PeerJ
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE, Directory of Open Access Journals
- Anahtar Kelimeler: Fibroscan, Elastography, Liver stiffness, MASLD, Prediabetes
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: Diabetes mellitus (DM) is associated with the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). In our study, we aimed to evaluate the relationship between liver stiffness (LS) and galectin-3 levels in patients diagnosed with prediabetes. Methods: A total of 120 participants were included in this prospective and cross-sectional study, comprising 40 patients with prediabetes, 40 patients with type 2 DM and 40 individuals with normal glucose metabolism. Human galectin-3 levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA) with Human Galectin-3 kits. LS measurements were performed using the FibroScanÒ Mini 430 device (Echosens, France). Results: In our study, we found that Fib-4 index, LS and galectin-3 levels were increased in patients with prediabetes. Another significant finding was that hemoglobin A1c (HbA1c) and galectin-3 levels were higher in patients with LS value ≥8 kPa and both HbA1c and galectin-3 levels were independently associated with LS. Conclusion: Considering the increased prevalence of MASLD in prediabetes, we recommend early assessment of LS and measurement of galectin-3 levels in these patients.