Evaluation of outcome prediction and disease extension by quantitative 2-deoxy-2-[ 18F] fluoro-D-glucose with positron emission tomography in patients with small cell lung cancer
Annals of Nuclear Medicine, cilt.25, sa.6, ss.406-413, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 6
- Basım Tarihi: 2011
- Doi Numarası: 10.1007/s12149-011-0478-y
- Dergi Adı: Annals of Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.406-413
- Anahtar Kelimeler: FDG-PET, Small cell lung cancer, Staging, Quantitative PET
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective The objective of this study is to determine whether 2-deoxy-2-[ 18F] fluoro-D-glucose with positron emission tomography (FDG-PET) imaging and quantitative PET parameters can predict outcome and differentiate patients with limited disease (LD) from extensive disease (ED) in patients with small cell lung cancer (SCLC). Methods We retrospectively evaluated data from 25 patients who underwent either initial staging (Group A, n 12) or restaging (Group B, n 13) by conventional imaging methods and FDG-PET according to the simplified staging scheme developed by the Veterans Administration Lung Cancer Study Group-2. FDG-PET images were both visually and quantitatively evaluated with SUV max, SUVave, total metabolic tumor volume (with SUV max>%50 and SUV max>2.5), total lesion glycolysis (Tlg) (with SUV max>%50 and SUV max>2.5). The correlation between quantitative PET parameters, disease stages and survival were analyzed. Results By conventional methods 14 of 25 (56%) patients were reported to have LD and 11 of 25 (44%) had ED. FDG-PET scan upstaged 9 out of 25 (36%) and downstaged 2 out of 25 (%8) patients. Among the quantitative PET parameters, Tlgs were the only PET parameters that differentiated between Group A and Group B patients. FDG-PET staging (p = 0.019) could predict significant survival difference between stages on contrary to conventional staging (p = 0.055). Moreover, Tlg [SUV max [%50] was the only quantitative PET parameter that could predict survival (p = 0.027). Conclusion FDG-PET imaging is a valuable tool in the management of patients with SCLC for a more accurate staging. The use of quantitative PET parameters may have a role in prediction of stage and survival. © The Japanese Society of Nuclear Medicine 2011.