Is Atopy Less Common in Helicobacter pylori-Positive Patients? A Retrospective Study Helicobacter pylori-Pozitif Hastalarda Atopi Daha mı Az Görülüyor? Retrospektif Bir Çalışma
Medical Journal of Bakirkoy, cilt.22, sa.2, ss.184-191, 2026 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 2
- Basım Tarihi: 2026
- Doi Numarası: 10.4274/bmj.galenos.2026.2025.7-4
- Dergi Adı: Medical Journal of Bakirkoy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CINAHL, EMBASE, TR DİZİN (ULAKBİM), Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Pharma Collection (ProQuest)
- Sayfa Sayıları: ss.184-191
- Anahtar Kelimeler: Atopy, eosinophil, Helicobacter pylori, IgE, monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, systemic inflammation, systemic inflammation response index
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: Helicobacter pylori (H. pylori) has been implicated in modulating systemic immune responses and may potentially influence the onset of atopic disorders. Nevertheless, its specific relationship with systemic atopic markers remains unclear. We investigated the link between H. pylori infection and systemic indicators of atopy by analyzing serum immunoglobulin E (IgE) levels alongside peripheral inflammatory parameters. Methods: In this retrospective analysis, data from 312 adult patients (246 females, 66 males) assessed for H. pylori infection between January 2023 and January 2025 were reviewed. Infection status was determined using stool antigen assays and/or histological examination of endoscopic biopsy specimens. Laboratory results included serum total IgE, eosinophil counts, complete blood count, C-reactive protein (CRP), and systemic inflammation markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation. Comparative statistical evaluations were performed between H. pylori-positive and -negative groups. Results: Serum IgE concentrations were not significantly different between H. pylori-positive and -negative individuals (median: 42.5 IU/mL vs. 37.5 IU/mL; p=0.891). Similarly, eosinophil counts and the majority of inflammatory indices exhibited no substantial variation. Notably, neutrophil counts were slightly elevated in the H. pylori-positive cohort (median: 4.00 vs. 3.60 x103/µL; p=0.043). Other markers, such as NLR, PLR, SII, SIRI, and CRP, did not differ significantly. Conclusion: H. pylori infection in adults was not associated with significant alterations in systemic atopic markers, including serum IgE and eosinophil counts, or with prominent changes in inflammatory indices. A mild rise in neutrophil levels may suggest a subtle systemic immune response rather than a marked inflammatory state.