Prognostic value of heparin-binding protein for mortality in severe COVID-19 pneumonia
Biomarkers in Medicine, cilt.16, sa.13, ss.981-991, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 13
- Basım Tarihi: 2022
- Doi Numarası: 10.2217/bmm-2022-0265
- Dergi Adı: Biomarkers in Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
- Sayfa Sayıları: ss.981-991
- Anahtar Kelimeler: biomarkers, COVID-19, diagnosis, emergency medicine, heparin-binding protein, infection, inflammation, mortality, pneumonia, prognosis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Aim: The study investigated heparin-binding protein (HBP) levels in patients with severe COVID-19 pneumonia and their relation to prognosis. Methods: A total of 134 patients with serious COVID-19 pneumonia were prospectively analyzed. HBP levels were statistically compared between both the patient and healthy control groups and within the patient group itself. Results: HBP was defined to be significantly higher in the patient group compared with the control group. There was a statistically significant distinction between the patients who survived and those who died with regard to HBP levels. When the cutoff value of HBP was >13.47, sensitivity (89.8%), specificity (74.1%) had area under the curve values of 0.806 (p < 0.001). Conclusion: HBP level may be used for prognosis prediction of patients with COVID-19.