Serum C-reactive protein levels in COPD patients after eight week comprehensive pulmonary rehabilitation program
Kuwait Medical Journal, cilt.50, sa.1, ss.66-71, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 1
- Basım Tarihi: 2018
- Dergi Adı: Kuwait Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.66-71
- Anahtar Kelimeler: exercise, inflammation, lung disease
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: To evaluate the effects of pulmonary rehabilitation (PR) program on C-reactive protein (CRP) levels and to identify the relationship between the changes in CRP levels with the outcome measures of PR with/without frequent comorbidities Design: The patients’ data before and after PR were evaluated retrospectively Setting: Ataturk Chest Diseases and Surgery Education and Research Hospital, Ankara, Turkey Subjects: One hundred and four stable, ex-smoker, chronic obstructive pulmonary disease (COPD) patients completing PR were enrolled into the study. Thirty-eight patients (36.5%) had a co-morbid disease. Intervention: Out-patient, multidisplinary, eight-week, comprehensive PR was performed Main outcome measure: Serum CRP levels Results: CRP levels decreased from 0.99 ± 1.50 to 0.62 ± 0.90 mg/dL. CRP level changes after PR were not significantly different in patients with/without comorbidities. Medical Research Council (MRC), St George’s Respiratory Questionnaire scales, incremental and endurance shuttle walk test (ISWT, ESWT) (all p < 0.001), body mass index (p = 0.038), FVC% (p = 0.032), FEV1% (p = 0.005) improved significantly in all patients. Baseline CRP levels only correlated with baseline ISWT (p = 0.037, r = -0.205), ESWT (p = 0.041, r = -0.201). Only improvements in FVC% and CRP level correlated significantly (p = 0.008). Conclusions: This study showed that there was negative correlation between CRP and exercise capacity in COPD patients and also, decreased CRP levels were associated with improvements in FVC.