Diagnostic impact of 18 F-FDG PET/CT on the management of rare breast carcinomas: Apocrine and neuroendocrine carcinomas Impacto diagnóstico de la PET/TC con 18 F-FDG en el tratamiento de carcinomas de mama raros: carcinomas apocrinos y neuroendocrinos
Revista Espanola de Medicina Nuclear e Imagen Molecular, cilt.38, sa.3, ss.147-153, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 38 Sayı: 3
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.remn.2018.11.007
- Dergi Adı: Revista Espanola de Medicina Nuclear e Imagen Molecular
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.147-153
- Anahtar Kelimeler: Apocrine breast carcinoma, Primary breast neuroendocrine carcinoma, P-18-PDG PET/CT
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: We aimed to evaluate the diagnostic impact of 18 F-FDG PET/CT in staging apocrine breast carcinoma (ABC)and primary breast neuroendocrine carcinoma (PBNEC)and to demonstrate possible alterations of the 18 F-FDG uptake in these histopathologic subtypes. In addition, we aimed to compare 18 F-FDG PET/CT findings between ABC, PBNEC and invasive ductal carcinoma. Material and methods: A total of 570 patients and 585 breast lesions were retrospectively included in this study. After patients were classified into molecular subtypes according to the histopathological analysis, 18 F-FDG PET/CT imaging was performed. The SUVmax findings of primary tumors obtained from 18 F-FDG PET/CT were compared between the groups. Results: Invasive ductal carcinoma was the most prevalent breast carcinoma (77.7%, n = 446), with a low proportion of ABC (4.1%, n = 24)and PBNEC (2.4%; n = 14)diagnosed. The highest mean SUVmax was calculated in HER2 subtype of ABC and 18 F-FDG uptake ratio in HER2 and TN subtypes were found statistically higher than Luminal B type of ABC (p = 0.038 and p = 0.019, respectively). Although 18 F-FDG uptake in Luminal B subtype of PBNEC was higher than Luminal A subtype, difference was not statistically significant. Additionally, the axillary metastasis rate was significantly higher in the ABC group (p = 0.015). Conclusions: The histopathological ABC subtype group showed different 18 F-FDG uptake than the invasive ductal carcinoma group. Even if 18 F-FDG uptake was lower in the PBNEC group than in the other groups, PET/CT showed and adequate performance in detecting primary tumors and metastases. The 18 F-FDG PET/CT scan results may contribute to the initial staging and management of ABC and PBNEC patients.