Acquired long QT syndrome and Torsades de Pointes related to donepezil use in a patient with Alzheimer disease
Egyptian Heart Journal, cilt.68, sa.3, ss.197-199, 2016 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 3
- Basım Tarihi: 2016
- Doi Numarası: 10.1016/j.ehj.2015.07.004
- Dergi Adı: Egyptian Heart Journal
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.197-199
- Anahtar Kelimeler: Donepezil, AChIs, Torsades de Pointes, QT prolongation, Syncope
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Acetylcholinesterase inhibitors are group of drugs commonly used in Alzheimer disease and have beneficial effects on treatment. Although they have many known side effects, cardiovascular side effects are rarely seen. We present a 84 year old female who was admitted to emergency service due to repetitive syncope episodes while taking donepezil. Her electrocardiogram showed QT prolongation and on follow-up a Torsades de Pointes episode occurred. Patient was discharged with normal corrected QT time after removal of donepezil.