Can we use serum SCUBE 1 levels as a biomarker in obstructive sleep apnea hypopnea syndrome?
Cranio - Journal of Craniomandibular and Sleep Practice, cilt.42, sa.5, ss.490-498, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 42 Sayı: 5
- Basım Tarihi: 2024
- Doi Numarası: 10.1080/08869634.2021.2005917
- Dergi Adı: Cranio - Journal of Craniomandibular and Sleep Practice
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.490-498
- Anahtar Kelimeler: Platelet activation, obstructive sleep apnea syndrome, SCUBE1, biomarker
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To examine the SCUBE1 level, a biomarker in vascular biology that could determine the prognosis of cardiovascular events during OSA treatment. Methods: In total, 129 patients were included in the study. Thirty were diagnosed with simple snoring and 99 with OSA. Results: In males, significant correlation was determined between SCUBE1 non-REM AHI, hypopnea index, total apnea index, mean SO2, minimum SO2, and < 90% saturation duration. Conclusion: Serum SCUBE1 levels increased more in male patients with severe OSA compared to other OSA levels, and high serum SCUBE1 levels were found to be associated with lower oxygen levels in OSA patients. The SCUBE1 biomarker can correlate with severe OSA in males. There was a statistically significant difference between OSA groups in terms of SCUBE1 score for male patients (p = 0.002) but not for females (p = 0.498). It is important that future SCUBE1 studies evaluate males vs. females.