Evaluation of the effects of berberine in the prevention of epidural fibrosis in rats An experimental research
Saudi Medical Journal, cilt.43, sa.4, ss.370-377, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.15537/smj.2022.43.4.20210918
- Dergi Adı: Saudi Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Arab World Research Source, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.370-377
- Anahtar Kelimeler: berberine, epidural fibrosis, laminectomy
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: To evaluate the effect of berberine)BBR(in preventing the development of epidural fibrosis)EF(after lumbar surgery in rats. Methods: This experimental study was carried out at the animal laboratory of Zonguldak Bülent Ecevit University, Zonguldak, Trurkey, between April 2020 and June 2020. A total of 32 Wistar albino female rats underwent laminectomy and were divided into 4 equal groups. Group 1 did not receive any treatment)control group(. In group 2, absorbable gelatin sponge was placed at the surgical site. Groups 3 was administered BBR 10 mg/kg and group 4 was administered BBR 60 mg/kg per oral per day for one week after laminectomy. All rats were sacrificed 6 weeks after the operation. Concentration of hydroxyproline )HP(in tissues and histopathological evaluations were carried out to evaluate the level of fibrosis. Results: Epidural fibrosis results in group 4 were significantly lower than those in groups 1 and 2)p≤0.001(. However, there was no significant difference between the mean EF degree between group 2 and group 3. Arachnoidal invasion in both group 3 and group 4 were significantly lower compared to group 1)p<0.05(. In terms of HP results, the difference between group 4 and group 1 was statistically significant)p<0.001(. Conclusion: This study provides preliminary evidence of the potential use of BBR for preventing the development of EF.