Evaluation of corneal, ocular surface, and meibomian gland changes in obstructive sleep apnea syndrome Évaluation des altérations de la cornée, de la surface oculaire et des glandes de Meibomius dans le syndrome d'apnée obstructive du sommeil
Journal Francais d'Ophtalmologie, cilt.45, sa.2, ss.191-200, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 2
- Basım Tarihi: 2022
- Doi Numarası: 10.1016/j.jfo.2021.09.007
- Dergi Adı: Journal Francais d'Ophtalmologie
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.191-200
- Anahtar Kelimeler: Meibomian gland, Meiboscore, Corneal endothelium, Obstructive sleep apnea syndrome
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To evaluate the ocular surface, eyelid changes, meibomian gland morphology, corneal endothelial morphology, and corneal topographic measurements in patients with obstructive sleep apnea syndrome (OSAS). Methods: There were 47 patients diagnosed with OSAS and 47 healthy volunteers included in the study. Non-invasive tear break-up time (NITBUT), corneal topography, meibography, and specular microscopy were performed. Results: The mean ages of the study and control groups were 45.77 ± 9.65 years and 44.26 ± 8.54 years, respectively (P = 0.229). The presence of floppy eye lid (17% vs. 0%; P = 0.006) and lid margin abnormality score (1.09 ± 0.8 vs. 0.21 ± 0.51; P < 0.001) were significantly different between the study and the control groups. There were insignificant differences between the groups in NITBUT and corneal topographic measurements, except for the ACT (556.96 ± 42.4 μm vs. 569 ± 103 μm, P = 0.037). The mean endothelial cell density (CD) in the OSAS and control groups were 2609 ± 259.96 and 2756 ± 179 cells/mm2, respectively (P = 0.002). Meibomian gland loss in the lower and upper eyelids was significantly higher in the OSAS group (P < 0.001 for both). Conclusion: OSAS patients develop eyelid margin abnormalities, loss of meibomian glands, and morphological changes in the meibomian glands. A significant reduction in corneal endothelial CD indicates that systemic hypoxia in OSAS has an effect on the cornea.