Chronic myelomonocytic leukemia developed 2 years after the onset of immune thrombocytopenic purpura like syndrome
Haematologia, cilt.30, sa.3, ss.221-224, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 30 Sayı: 3
- Basım Tarihi: 2000
- Doi Numarası: 10.1163/156855900300109233
- Dergi Adı: Haematologia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.221-224
- Anahtar Kelimeler: chronic myelomonocytic leukemia, immune thrombocytopenic purpura
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
An 80-year old man was diagnosed as having immune thrombocytopenic purpura based on epistaxis, purpura and by the platelet count 8 x 109/1. Prednisolone and gamma globulin were administered and the platelet count had been kept around 50 x 109/1 during his follow up. Two years from the onset of immune thrombocytopenic purpura he was admitted because of leukocytosis (79 x 109/1 with 79% monocytes), anemia and thrombocytopenia. Hypercellular bone marrow with dysplasia of three lineages was observed. In the bone marrow cytogenic analysis, a -6, clonal cytogenic abnormality was observed, 45XY, der(6), t(6;6)(q16;q23). He was diagnosed as having chronic myelomonocytic leukemia. This is a difficult case in which it was diagnosed as refractory thrombocytopenia as a subgroup of myelodysplastic syndrome, rather than immune thrombocytopenic purpura, which might have preceded the development of chronic myelomonocytic leukemia.