Incidence of persistent renal dysfunction and long-term survival after coronary computed tomography angiography
Cardiovascular journal of Africa, cilt.36, sa.3, ss.244-248, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 36 Sayı: 3
- Basım Tarihi: 2025
- Doi Numarası: 10.5830/cvja-2025-032
- Dergi Adı: Cardiovascular journal of Africa
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.244-248
- Anahtar Kelimeler: coronary computed tomography angiography, renal dysfunction, survival
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
BACKGROUND: Renal impairment following contrast exposure can sometimes become permanent, and data on the long-term impact of coronary computed tomography angiography (CTA) on renal dysfunction are limited. We aimed to examine the incidence and long-term outcome of persistent renal dysfunction after coronary CTA. METHODS: We identified 3500 patients with creatinine levels measured before and six months after coronary CTA. A total of 2054 patients were included in the final analysis for contrast-induced nephropathy (CIN) diagnosis, defined as a serum creatinine increase of 0.5mg/dl or a relative increase of 25% from baseline. Persistent renal dysfunction was defined as an absolute increase of 0.5 mg/dl or a relative increase of 25% in creatinine levels after at least six months of follow-up. RESULTS: The incidence of CIN was 1.0% and 40 (1.9%) patients had persistent renal dysfunction at median 2.5-year follow-up. Mortality rate was 2.0% (41 patients) and four patients (0.2%) required permanent dialysis during the same period. In multivariate regression analysis; age (odds ratio [OR]: 1.050, p = 0.027), diabetes (OR: 2.769, p = 0.004), baseline renal function (OR: 0.967, p = 0.003), and occurrence of CIN (OR: 7.760, p = 0.002) were identified as independent predictors of persistent renal dysfunction. Furthermore, occurrence of CIN and persistent renal dysfunction were found as independent predictors of long-term mortality. CONCLUSION: During follow-up after coronary CTA, the incidence of persistent renal dysfunction was 1.9%, and the occurrence of CIN was the most important risk factor. In addition, both CIN and persistent renal dysfunction were associated with long-term mortality.