Assessment of Serum Zinc and Selenium Levels in Children with COVID-19
Journal of Pediatric Infectious Diseases, cilt.17, sa.5, ss.258-263, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 5
- Basım Tarihi: 2022
- Doi Numarası: 10.1055/s-0042-1756714
- Dergi Adı: Journal of Pediatric Infectious Diseases
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database
- Sayfa Sayıları: ss.258-263
- Anahtar Kelimeler: zinc, selenium, COVID-19 in children
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective Zinc and selenium levels are being investigated with increasing frequency in adult patients with coronavirus disease 2019 (COVID-19). However, levels of zinc and selenium in children with COVID-19 have not been adequately studied to date. Methods This prospective, observational study was conducted on 146 pediatric patients diagnosed with COVID-19 and 49 healthy controls between 2020 and 2021. Normal serum zinc reference values were 0.60 to 1.20 μg/mL for children 0 to 10 years old and 0.66 to 1.10 μg/mL for children ≥11 years old. The normal range for serum selenium concentration was considered between 70 and 150 μg/L. Deficiencies were defined for values below the reference range. Results Zinc and selenium levels were significantly lower in the COVID-19 (+) group compared with the controls (zinc: 0.7±0.2 vs 0.9±0.2 μg/mL, p < 0.001; selenium: 57.1±9.1 vs 66.5±11.4 μg/L, p < 0.01, respectively). Also, zinc and selenium levels were found to be statistically significantly lower in the hospitalized group compared with the outpatient group (zinc: 0.6±0.2 vs 0.8±0.2 μg/mL, p < 0.001; selenium: 52.1±9.6 vs 58.8±8.3 μg/L, p < 0.001). In the receiver operating characteristic curve analysis, selenium levels with a cutoff value of 55.50 μg/L, with 75% sensitivity and 70% specificity, and zinc levels with a cutoff value of 0.7 μg/mL, with 56% sensitivity and 53% specificity, predicted hospitalization. Conclusion Our data showed that serum zinc and selenium levels were significantly lower in patients with COVID-19 compared with healthy control group. Also, zinc and selenium levels were found to be lower in the hospitalized group compared with the outpatient COVID-19 group.