The effect of bile acids in bacterial translocation in obstructive jaundice in rats TIKANMA SARILIKLI SICANLARDA BAKTERIYEL TRANSLOKASYONA SAFRA TUZLARININ ETKISI
Klinik Gelisim, cilt.8, sa.8, ss.3776-3779, 1995 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 8
- Basım Tarihi: 1995
- Dergi Adı: Klinik Gelisim
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.3776-3779
- Anahtar Kelimeler: Bacterial translocation, Bile acids, Obstructive jaundice
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Thirty male Sprague-Dawley rats were randomly divided into three groups in which group I received a sham operation (controls), group II and III underwent common bile duct ligation. Animals in group I and II received saline orally, while group III received an oral administration of ursodeoxycholic acid (10 mg/kg/day). Specimens were taken for bacterial culture. The rate of positive bacterial cultures in jaundiced saline-treated animals was significantly higher (p≤0.05) as compared with both controls and the other jaundiced animals treated with bile acid. We conclude that oral administration of ursodeoxycholic acid inhibited bacterial translocation in obstructive jaundiced rat.