Increased acylation stimulating protein concentrations in nonalcoholic fatty liver disease are associated with insulin resistance

Yesilova Z., Ozata M., Oktenli C., Bagci S., Ozcan A., Sanisoglu S. Y., ...Daha Fazla

American Journal of Gastroenterology, cilt.100, sa.4, ss.842-849, 2005 (Scopus)

Özet

OBJECTIVES: As acylation stimulating protein (ASP) acts on adipocytes mainly as a paracrine factor to increase triglyceride synthesis and storage; hypothetically, it may play a similar role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). METHODS: Forty-six male patients with NAFLD (group A), age-matched 30 male patients with chronic viral hepatitis (group B) and 30 age-matched and body mass index (BMI)-matched healthy male subjects were enrolled in the study. RESULTS: Among the NAFLD patients, 10 patients (24.4%) had simple steatosis and 36 patients (69.6%) had nonalcoholic steatohepatitis (NASH). The mean levels of ASP, complement 3, insulin, C-peptide, HOMA-IR, triglyceride, and very low-density lipoprotein (VLDL) were significantly higher in group A patients than both controls and group B. ASP levels correlated significantly in a positive manner with BMI, insulin, and HOMA-IR. CONCLUSIONS: Dysregulation of the ASP pathway may have important metabolic consequences in NASH and is associated with insulin resistance. © 2005 by Am. Coll. of Gastroenterology. Published by Blackwell Publishing.