CAN NEUTROPHIL/LYMPHOCYTE RATIO BE USED AS AN INDICATOR OF INFLAMMATION IN PATIENTS WITH HYPERTHYROIDISM? DA LI SE ODNOS NEUTROFILA/LIMFOCITA MO@E KORISTITI KAO INDIKATOR UPALE KOD PACIJENATA SA HIPERTIREOIDIZMOM?

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Dağdeviren M., AKKAN T., Yapar D., KARAKAYA S., Dağdeviren T., Ertuğrul D., ...Daha Fazla

Journal of Medical Biochemistry, cilt.39, sa.1, ss.7-12, 2020 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.2478/jomb-2019-0004
  • Dergi Adı: Journal of Medical Biochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.7-12
  • Anahtar Kelimeler: hyperthyroidism, lymphocyte, neutrophil, ratio
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Background: In our study, we aimed to evaluate changes in the neutrophil and lymphocyte series and investigate whether the neutrophil/lymphocyte ratio (NLR) is indicative of inflammations in patients with hyperthyroidism. Methods: A total of 161 patients were enrolled, 121 of which had hyperthyroidism (71 Graves’ Disease (GD) and 50 non-Graves hyperthyroidism (NGH) patients) and 40 of which were control group members. Retrospectively, patients’ neutrophil and lymphocyte counts were taken, and the NLR was calculated. Results: While the number of neutrophils was significantly lower in the GD group (p = 0.003), there was no significant difference between the NGH and the control group. In the GD group, NLR values were significantly lower than the other two groups (median 1.39 for GD, median 1.84 for NGH and median 1.83 for the control group, p < 0.001). Only three patients in the GD group had neutropenia. There was also a significant negative correlation between free T3 and neutrophil count and NLR in hyperthyroid patients (r = –0.28, p = 0.001 and r = –0.34, p < 0.001, respectively). Conclusions: In our study, we found that NLR did not increase in hyperthyroid patients and that this ratio decreased due to the decrease in neutrophil levels in GD. We thus concluded that NLR is not a suitable indicator of hyperthyroidism.