The role of NMDAR antibody in the etiopathogenesis of schizophrenia
Neuropsychiatric Disease and Treatment, cilt.12, ss.2327-2332, 2016 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 12
- Basım Tarihi: 2016
- Doi Numarası: 10.2147/ndt.s113872
- Dergi Adı: Neuropsychiatric Disease and Treatment
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.2327-2332
- Anahtar Kelimeler: schizophrenia, N-acetyl D-aspartate receptor, glutamate, antibody
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Many authors have reported the presence of serum NMDAR antibodies in varying proportions of patients with schizophrenia; however, many others have not been able to confirm this. Because of the contradictory findings reported in various studies, more definitive research on this issue is required. Hence, we have investigated the NR1 subunit of NMDAR antibodies in patients with schizophrenia (n=49) and healthy controls (n=48). None of the investigated patients with schizophrenia and none of the healthy controls showed positive antibody against the NR1 subunit of the NMDAR. On the basis of this result, we conclude that the NR1 subunit of the NMDAR antibodies does not seem to have a role in schizophrenia.