Effects of oral glutamine on radiation-induced laryngeal mucosal damage
Head and Neck Oncology, cilt.5, sa.4, 2013 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 5 Sayı: 4
- Basım Tarihi: 2013
- Dergi Adı: Head and Neck Oncology
- Derginin Tarandığı İndeksler: Scopus
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Purpose: To evaluate the influence of glutamine on radiation-induced laryngeal mucosal damage in an experimental model. Methods: The study was conducted at the animal care facility of Istanbul University Institute of Experimental Medicine. Sixteen adult Spraque Dawley rats weighing 200-220 g were used for this study. Radiotherapy was delivered with a 6 MV linear accelerator with two opposed lateral fields. 2000 cGy was given with single fraction to the neck. The animals were randomized into two groups of 8 rats each. Animals in Group I (control group) was fed with standard chow and water, those in Group II was fed with glutamine 2 g/kg/day additional to standard chow and water. All the animals were sacrificed two weeks later with a barbiturate overdose. The larynx was removed and hystopathological changes were measured in laryngeal mucosa. Results: Subepithelial edema and keratosis was higher in Group I than Group II (the p values was 0.012 and 0.034 respectively). Vascular engorgement was higher in Group I but not statistically significant (p:0.105). There was a significant difference in cartilage degeneration developed in rats receiving standard diet compared to those received glutamine (p = 0.001). Intraepithelial lymphocyte (IEL) infiltration and inflammation was higher in Group I versus Group II but not statistically significant (p:0.085 vs. p:0.157 respectively). Conclusion: Glutamine can accelerate mucosal healing and regeneration in laryngeal mucosa after experimental head and neck irradiation.