The effects of metformin and metformin plus calcium treatments on serum vitamin B12 levels Metformi̇n ve metformi̇n+kalsi̇yum tedavi̇leri̇ni̇n serum B12 vi̇tami̇n düzeyleri̇ üzeri̇ndeki̇ etki̇leri̇
Nobel Medicus, cilt.9, sa.3, ss.58-63, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 3
- Basım Tarihi: 2013
- Dergi Adı: Nobel Medicus
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.58-63
- Anahtar Kelimeler: Calcium, Homocysteine, Metformin
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: It is well known that patients with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM) on metformin therapy, may be exposed to vitamin B12 deficiency. Our study aimed to compare the effects of metformin versus metformin plus calcium treatments on serum vitamin B12 levels in newly diagnosed T2DM and IFG patients. Material and Methods: The study patients with a new diagnosis of T2DM and IFG were randomised into two groups; one group received metformin; daily 2x1000 mg (group 1), while the other group received metformin; 2x1000 mg/d plus oral calcium supplements; 1x1000 mg/d (group 2) in a 3 month-period. Fasting blood glucose, vitamin B12, lipid parameters, HbA1c and homocysteine levels were compared before and after the treatment. Results: The study included 48 patients, 22 women (45.8%) and 26 men (54.2%). There were 12 men (46,2%) and 14 women (53.8%) in group 1, 14 men (63.6%) and 8 women (36.4%) in group 2. Mean ages were 54.77±7.59 (36-65) and 53.45±9.15 (35-65) years in group 1 and 2, respectively. When pre and post treatment biochemical parameters in group 1 were compared, significant reductions in serum vitamin B12, lipid parameters, HbA1c and fasting blood glucose levels were found following the treatment. In group 2, there were also significant reductions in serum homocysteine vitamin B12, HDL-chol, triglyceride and fasting glucose levels after the treatment. When serum vitamin B12 levels were compared before and after the treatment, although the difference was not statistically significant, the decrease in serum vitamin B12 levels in group 2 was found to be 26.60 pg/ml lower than in group 1. Conclusions: We found that vitamin B12 levels decreased less with metformin plus calcium therapy compared to only metformin therapy. It may be suggested that additional calcium supplements may prevent B12 vitamin deficiency and associated complications in patients on metformin therapy. Further studies regarding this suggestion are needed.