Correlations of the 68Ga-PSMA PET/CT derived primary prostate tumor PSMA expresstion parameters and metastatic patterns in patients with Gleason Score >7 prostate cancer
Hellenic Journal of Nuclear Medicine, cilt.23, sa.2, ss.120-124, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 2
- Basım Tarihi: 2020
- Dergi Adı: Hellenic Journal of Nuclear Medicine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Sayfa Sayıları: ss.120-124
- Anahtar Kelimeler: 68Ga-PSMA PET/CT, Metastasis, PSMA expression parameters
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objectives: We aimed to investigate the correlations between the prostate specific membrane antigen 68(PSMA) expression parameters of the primary prostate tumor on gallium-68( Ga)-PSMA positron emission tomography/computed tomography (PET/CT) with metastatic patterns in patients with Gleason Score 68(GS) >7 prostate cancer (Pca). Materials and Methods: This study included 55 PCa patients who had Ga- PSMA PET/CT performed for staging. According to metastatic pattern, patients were divided into 3 groups as non-metastatic (N0M0), those with isolated pelvic lymph node metastasis (N1M0) and with distant metastasis (M1). The correlations between the primary tumor PSMA expression parameters such as maximum standardize uptake value (SUVmax), SUVmean, PSMA-TV (PSMA receptor expressing tumour volume), and 68 TL-PSMA (total lesion PSMA receptor expression) on Ga-PSMA PET/CT imaging and metastatic patterns were investigated. Results: There were 21, 9 and 25 patients in the N0M0, N1M0 and M1 groups, respectively. The PSMA-TV and TL-PSMA values were significantly higher in the N1M0 and the M1 patient groups compared to the N0M0 group, but there was no significant difference between the N1M0 and M1 groups. The primary tumor SUVmax and SUVmean values were not significantly different between the three gro- 3 ups. The optimal PSMA-TV cut-off value for metastasis was >8.07cm (AUC 0.86) with sensitivity of 76.5% and specificity 85.7%. The optimal TL-PSMA cut-off value for metastasis was >93 (AUC 0.74) with sensitivity of 64%, and specificity 100%. Conclusion: The PSMA-TV and TL-PSMA values are strong markers for metastasis prediction in patients with GS >7 PCa but no other PSMA expression parameters can distinguish between N1M0 and M1 groups.