Effect of Mobilization Methods on CD34+ and Total Nucleated Cell Count and Their relation with Engraftment in Autologous Hematopoietic Stem Cell Transplantation
Eastern Journal of Medicine, cilt.29, sa.3, ss.344-348, 2024 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 3
- Basım Tarihi: 2024
- Doi Numarası: 10.5505/ejm.2024.08624
- Dergi Adı: Eastern Journal of Medicine
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.344-348
- Anahtar Kelimeler: CD34, engraftment, Stem cell
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Effective stem cell mobilization is crucial for autologous hematopoietic stem cell transplantation (auto-HSCT), impacting engraftment time and patient outcomes. This study compared three mobilization regimens (G-CSF alone, G-CSF & plerixafor, and chemotherapy & G-CSF) to determine their optimal use for maximizing CD34+ cell yield and minimizing engraftment times. A retrospective analysis of 227 auto-HSCT patients was conducted. Mobilization groups, CD34+ cell counts, total nucleated cells (TNC), total mononuclear cells (TMNC), and platelet/neutrophil engraftment times were analyzed. The average engraftment time was 11.6 days for platelets and 10.6 days for neutrophils. The chemotherapy & G-CSF arm yielded the highest CD34+ cells (p=0.001) and lowest TNC/TMNC (p=0.000). This arm also achieved the fastest platelet engraftment (p=0.017-0.001). Notably, age positively correlated with TNC count (p=0.022) and prolonged neutrophil engraftment (p=0.021). Gender did not significantly influence engraftment times. The chemotherapy & G-CSF regimen yielded the highest CD34+ cell count, lowest TNC/TMNC, and fastest platelet engraftment. However, neutrophil engraftment was positively associated with age, suggesting additional factors influence this outcome. Optimizing mobilization strategies and considering patient age are crucial for optimizing auto-HSCT outcomes.