Alternative volumetric PET pjmirometers for evaluation of breast cancer cases with 18F-FDG PET/CT imaging: Metabolic tumour volume and total lesion glycolysis
Journal of Medical Imaging and Radiation Oncology, cilt.65, sa.1, ss.38-45, 2021 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 65 Sayı: 1
- Basım Tarihi: 2021
- Doi Numarası: 10.1111/1754-9485.13114
- Dergi Adı: Journal of Medical Imaging and Radiation Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
- Sayfa Sayıları: ss.38-45
- Anahtar Kelimeler: breast cancer, F-18-fluorodeoxyglucose positron emission tomography, computed tomography, metabolic tumour volume, total lesion glycolysis
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: We aimed to investigate the prognostic and clinical values of two volumetric PET pjmirometers used in conjunction with SUVmax at different thresholds in invasive ductal carcinoma (IDC). Methods: A total of 139 metastatic IDC BC who underwent 18F-FDG PET/CT imaging were included to study. MTV and TLG (40%, 50%, 60% and 70%) used in conjunction with primary tumour SUVmax. Nodal involvement, distant metastasis, ER, PR, Ki-67 expression and survival data evaluated by comparing FDG PET pjmirometers. Results: Mean ± SD SUVmax of lesions (n = 139) was 13.97 ± 9.21. Primary tumour 18F-FDG uptake associated increased tumour diameter (>2 cm), high Ki-67 (>15%) and distant organ metastasis (DOM) (P = 0.015, 0.005 and 0.016, respectively). There was significant association between molecular subtypes and SUVmax (P = 0.002). High MTV associated with tumour diameter (MTV 40–70%), axillary lymph node (ALN) diameter (MTV 40–70%), and distant nodal metastasis (DNM) (MTV 50–70%). High TLG associated with tumour diameter (TLG 40–70%), high Ki-67 (TLG 40–70%), ALN metastasis (TLG 40%), ALN diameter (TLG 40–70%) and DNM (TLG 40–70%). Median survival found shorter in DOM patients (P = 0.030, Log Rank = 0.110). Conclusion: We think evaluation of MTV and TLG at different thresholds in addition to SUVmax would enhance diagnostic and prognostic value of 18F-FDG PET/CT, and thus contribute to disease management.