Neuromuscular effects of atracurium and mivacurium administered alone and in combination Mivakuryum ve atrakuryumun birlikte ve tek basina kullanimlarinda noromuskuler etkiler
Turk Anesteziyoloji ve Reanimasyon, cilt.27, sa.3, ss.131-136, 1999 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 3
- Basım Tarihi: 1999
- Dergi Adı: Turk Anesteziyoloji ve Reanimasyon
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.131-136
- Anahtar Kelimeler: Acceleromyography, Atracurium, Mivacurium
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
The current study was undertaken to compare the neuromuscular blockade characteristics produced by atracurium and mivacirum in combination with that produced by each drug alone with acceleromyographic method. We studied in 30 ASA I and II patients, aged 18-60 yr. Anaesthesia was induced with propofol 2 mg/kg and was maintained with % 1-1.5 halothane % 50 N2O and O2. The patients were randomly allocated to 3 groups of 10 patients each to receive atracurium 0.5 mg/kg in Group I, mivacurium 0.15 mg/kg in Group II and atracurium 0.25 mg/kg+mivacurium 0.075 mg/kg in Group III and onset time, clinical duration, TOF 75 duration and recovery index were determined in each group. Onset times in mivacurium and atracurium combined group was significantly longer than that observed in mivacurium group (p<0.05). Clinical duration of action was significantly greater in Group III (atracurium+mivacurium group) than with mivacurium (p<0.001). There was no significantly differences in recovery index between groups. We conclude that mivacurium was became intermediate clinical duration after combined atracurium-mivacurium induced neuromuscular block and reverse characteristics of atracurium+mivacurium was similar to each drug alone.