Association between carotid intima-media thickness and acute kidney injury following isolated coronary artery bypass surgery
Cardiovascular Journal of Africa, cilt.34, sa.4, ss.198-205, 2023 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34 Sayı: 4
- Basım Tarihi: 2023
- Doi Numarası: 10.5830/cvja-2022-035
- Dergi Adı: Cardiovascular Journal of Africa
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.198-205
- Anahtar Kelimeler: coronary artery bypass grafting, acute kidney injury, carotid intima-media thickness
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The association between pre-operative carotid intima-media thickness (CIMT) and early postoperative acute kidney injury (AKI) following isolated coronary artery bypass grafting (CABG) was investigated. Methods: Data were sought retrospectively of 237 patients (166 male, 71 female; mean age 61.4 ± 8.1 years; range: 32-74), operated on for isolated CABG with cardiopulmonary bypass (CPB) in a single centre between June 2014 and December 2020, with a serum creatinine level < 1.5 mg/dl and normal carotid arteries on Doppler ultrasonography. AKI diagnosis was made according to the Kidney Disease Improving Global Outcomes 2012 Acute Kidney Injury Guideline. Patients were grouped as group 1 with AKI in the early postoperative period (n = 63) and group 2 without AKI (n = 174). Univariate analyses were done to determine significant clinical factors, and subsequent multiple logistic regression analysis was done to determine independent predictors of AKI. Results: AKI occurred in 63 (26.6%) patients. Pre-operative CIMT was significantly higher in the AKI group (p = 0.0001). Multivariate logistic regression analysis revealed that elevated pre-operative CIMT (p = 0.005), C-reactive protein (p = 0.001), erythrocyte sedimentation rate (p = 0.005), neutrophil-lymphocyte ratio (p = 0.0001) and platelet-lymphocyte ratio (p = 0.0001) increased on the postoperative seventh day. C-reactive protein (p = 0.04), postoperative first day platelet-lymphocyte ratio (p = 0.0001), postoperative seventh day erythrocyte sedimentation rate (p = 0.02) and intubation time (p = 0.02) were independent predictors of early postoperative AKI following isolated CABG. Conclusion: Pre-operative CIMT was found to be an independent predictor of AKI in the early postoperative period of isolated CABG.