Secondary acute myeloblastic leukemia in a child with acute lymphoblastic leukemia treated with epipodophyllotoxins
Turkish Journal of Pediatrics, cilt.37, sa.3, ss.279-282, 1995 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 37 Sayı: 3
- Basım Tarihi: 1995
- Dergi Adı: Turkish Journal of Pediatrics
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.279-282
- Anahtar Kelimeler: acute lymphoblastic leukemia, etoposide, secondary acute myeloblastic leukemia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Etoposide is a semi-synthetic, topoisomerase active podophyllotoxin derivative which frequently causes deletions and rearrangements on chromosomes 11q23 and 11q22. It can cause therapy-related, acute myeloblastic leukemia in patients receiving the drug in a schedule-dependent manner. Here we present a case with acute lymphoblastic leukemia who developed secondary acute myeloblastic leukemia 28 months after the beginning of therapy which contained etoposide on an every-other-week schedule.