Diagnostic Value of Platelet Indices in Pulmonary Thromboembolism: A Retrospective Analysis
Clinical and Applied Thrombosis/Hemostasis, cilt.31, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 31
- Basım Tarihi: 2025
- Doi Numarası: 10.1177/10760296251388987
- Dergi Adı: Clinical and Applied Thrombosis/Hemostasis
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Anahtar Kelimeler: pulmonary embolism, mean platelet volume, platelet distribution width, emergency medicine, hematological parameters
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: Timely and accurate diagnosis of pulmonary thromboembolism (PTE) in the emergency department (ED) is critical, yet remains challenging due to non-specific clinical features. Platelet indices have recently emerged as potential biomarkers, but their diagnostic utility is uncertain. Methods: In this retrospective single-center study, 1198 adult patients who underwent CT pulmonary angiography for suspected PTE in a tertiary ED were analyzed. Demographic characteristics and a comprehensive panel of hematological, biochemical, and coagulation parameters were compared between PTE (n = 126) and non-PTE (n = 1072) groups. Multivariate logistic regression and ROC curve analyses were performed to assess independent predictors and diagnostic performance. Results: Platelet indices including platelet count, mean platelet volume, platelet distribution width, plateletcrit, and derived ratios showed no significant differences between groups. However, PTE patients were older, more likely female, and exhibited significantly lower red blood cell count, hemoglobin, hematocrit, and higher neutrophil count (all P < .05). Multivariate analysis identified lower RBC and higher neutrophil count as independent predictors, while female sex was associated with decreased PTE risk. The model's discriminative ability was modest (AUC = 0.651). Conclusion: Platelet indices do not provide diagnostic value for PTE in the ED. Traditional demographic and hematological markers may aid risk stratification, but clinical integration remains essential. Prospective studies are needed to validate these findings and enhance diagnostic pathways.