Familial Mediterranean fever acute crisis prolongs Q-T interval Ailesel akdeniz ateşi akut krizi Q-T intervalini uzatir
Goztepe Tip Dergisi, cilt.21, sa.1, ss.32-35, 2006 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 1
- Basım Tarihi: 2006
- Dergi Adı: Goztepe Tip Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.32-35
- Anahtar Kelimeler: Arrhytmia, Familial Mediterranean fever, Q-T dispersion
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: To investigate the Q-T interval and Q-T dispersion in acute crisis of familial Mediterranean fever. Material and methods: Thirty-four patients during their acute crisis of familial Mediterranean fever (FMF) constituted the study group, while 30 healthy men were included in the control group. Any case taking medications known to effect Q-T interval was excluded from the study. Q-T interval was measured from the EKG before therapy in the study group. Electronic calipers were utilized after obtaining the 12-lead surface ECG recordings, which were scanned at a high resolution and transferred to computer. R-R intervals, maximum and minimum Q-T intervals, which were corrected according to Bazett formula were compared by t test. Results: The age distribution of FMF didn't differ in both groups (study group 21±1, control group 21±2 years). The average duration of the illness were 10±5 years and the familial incidence of this disease was found 26%. The corrected Q-Tmax was measured as 425±37 msec and 447±27 msec (p=0.045), the corrected Q-Tmin was 361±24 msec and 396±17 msec (p<0.0005), corrected Q-T (Q-Tc) dispersion was 65±33 msec and 51±15 msec (p=0.09). Conclusion: Acute FMF crisis prolongs Q-T interval but did not differ Q-T dispersion. Although we don't know the clinical significance of this prolongation, the drugs using for the treatment can prolong Q-T interval and cause potential arrhythmias and the proarrhytmic properties of these drugs become evident.