Comparison of the levels of the serotonin metabolite, 5-hydroxyindole acetic acid, in cerebrospinal fluid from patients with and without premature ejaculation Comparación de los niveles de ácido 5-hidroxindolacético, metabolito de la serotonina, en el líquido cefalorraquídeo de pacientes con y sin eyaculación precoz
Revista Internacional de Andrologia, cilt.17, sa.2, ss.41-45, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 2
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.androl.2018.01.001
- Dergi Adı: Revista Internacional de Andrologia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.41-45
- Anahtar Kelimeler: Premature ejaculation, Cerebrospinal fluid, 5-Hydroxyindol acetic acid levels
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Premature ejaculation (PE) is a significant problem as it can cause a loss of sexual self-confidence and a significant deterioration in quality of life. The frequency of PE varies between 9% and 27%. In the current study, we aimed to compare the levels of the serotonin metabolite 5HIAA (5 hydroxyindole acetic acid) in the cerebrospinal fluid (CSF) of patients with and without PE according to IELT (intravaginal ejaculation latency time) in order to investigate the relationship of PE with CSF 5HIAA levels. Materials and methods: A total of 60 male patients were included in the study who were planning to undergo surgery under spinal anesthesia, 30 in the patient (PE) group (all of the included patients had an IELT of <1 min) and 30 in the control group (patients had an IELT of >1 min). Levels of CSF 5HIAA were measured. Results: There was a significant negative correlation between IELT and the 5HIAA variables in all patients (r = −0.322, p = 0.012). Although the average 5HIAA levels (nmol/L) were higher in the patient group (86.80 ± 28.33) than in the control group (76.44 ± 35.91), this difference was not significant (p = 0.22). Discussion: Results of the current study bring new and different perspectives to the explanation of PE pathophysiology. There is a need for more specific and genetic studies to determine the best treatment for this common disorder.