The role of secondary chromosomal abnormalities in the progression of chronic myeloid leukemia cases Kronik miyelositer lösemi olgularinda philadelphia kromozomu haricindeki sitogenetik anomalilerin prognoza etkisi
Turkiye Klinikleri Journal of Medical Sciences, cilt.25, sa.2, ss.174-177, 2005 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 2
- Basım Tarihi: 2005
- Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.174-177
- Anahtar Kelimeler: Chromosome aberations, Leukemia, Myeloid, Philadelphia chromosome, Trisomy
- Sağlık Bilimleri Üniversitesi Adresli: Hayır
Özet
Objective: Chronic myeloid leukemia is a clonal bone marrow disease characterized by neoplastic overproduction of granulocytes. Nearly all chronic myeloid leukemia patients possess a single cytogenetic abnormality, t(9; 22)(q34; q11), termed the Philadelphia chromosome (Phl). In the disease progression phase, a variety of chromosomal abnormalities have been reported with and without the presence of the Philadelphia chromosome. Material and Methods: Here we present cytogenetic analyses of 48 patients diagnosed with chronic myeloid leukemia. The results were correlated with clinical findings. Results: The Phl chromosome presented in 93.7% of all patients during the initial diagnostic phase. No other cytogenetic abnormality was evident. During the treatment phase, seven cases manifested extra chromosomal abnormalities (with six evincing the Phl chromosome in the initial diagnostic phase). In four cases in which extra chromosomal abnormality was noted, blastic transformation occurred. By contrast, blastic transformation developed in only two out of 42 cases with Phl chromosome abnormality. In one out of three Phl-negative cases, blastic transformation was observed. This observation was short-lived due to the progression of the disease. Finally, in two patients, trisomy 8 without the Phl chromosome finding was seen. Conclusion: Cytogenetic abnormalities similar to those noted in our study of chronic myeloid leukemia have been reported in the literature. These results underline the importance of the secondary chromosomal abnormalities that occur during the disease treatment phase. Copyright © 2005 by Türkiye Klinikleri.