The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy
Journal of Perinatal Medicine, cilt.33, sa.2, ss.121-124, 2005 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 2
- Basım Tarihi: 2005
- Doi Numarası: 10.1515/jpm.2005.023
- Dergi Adı: Journal of Perinatal Medicine
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.121-124
- Anahtar Kelimeler: amino-terminal probrain natriuretic peptide (Nt pro-BNP), normotensive pregnancy, preeclampsia
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Objective: The purpose of this study was to evaluate the levels of amino-terminal probrain natriuretic peptide (Nt pro-BNP) in preeclampsia in comparison with normotensive pregnancy. Materials and methods: Women with preeclampsia (proteinuria ≥300 mg/24 h and at least two readings of systolic blood pressure ≥140 mm Hg and diastolic blood pressure >90 mm Hg) (n=32 mild preeclampsia and n=8 severe preeclampsia) were compared with normotensive women (n=40). Serum Nt pro-BNP was measured using an electrochemiluminescence immunoassay (ECLIA) method (Nt pro-BNP, Roche) with a Roche modular analytics E170 immunoassay analyzer. Statistical analysis was carried out by the Student t-test, and a P value of <0.05 was accepted as statistically significant. Results: The median serum Nt pro-BNP was 430 ± 28.91 pg/mL in preeclampsia. The levels of serum Nt pro-BNP were 74 ± 16.82 pg/mL in normotensive pregnant women (P < 0.001)and significantly higher in women with preeclampsia (P < 0.001). Conclusion: The higher levels of serum Nt pro-BNP in preeclamptic women may be an indicator of high left-ventricular filling pressure, and indicate left-ventricular diastolic dysfunction.