False resistance after artemether–lumefantrine treatment in a falciparum malaria patient in Turkey: A case report
IDCases, cilt.18, 2019 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.idcr.2019.e00607
- Dergi Adı: IDCases
- Derginin Tarandığı İndeksler: Scopus
- Anahtar Kelimeler: Malaria, P. falciparum, Artemisinin-based combination therapy
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization as first-line treatment of uncomplicated Plasmodium falciparum malaria. ACT treatments failures among travellers returning from Africa to non-endemic countries are considered to be caused by resistance. Case presentation: We report on a case of artemether-lumefantrine treatment failure in a Turkish traveller with uncomplicated P. falciparum malaria returning from Bamako, Mali. Conclusions: Information on returning travellers, includes ensuring that the patients receive supervised treatment with the recommended dose of a quality controlled medicine, routine follow-up of all cases, assessment of adequate absorption of the drug, and/or testing the prevalence of molecular markers of drug resistance if validated, can be an important source of an early warning system for emerging resistance.