Vitamin D in Patients with Cardiac Syndrome X and its Relationship with Inflamatuar and Oxidative Stress Markers: A Case Control Study Kardiyak Sendrom X Hastalarında D Vitamini ve Bunun İnflamatuar ve Oksidatif Stres Belirteçleri ile İlişkisi: Vaka-Kontrol Çalışması

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ÜSTÜNDAĞ Y., TOPAL D., Er F., HUYSAL K.

Turkiye Klinikleri Cardiovascular Sciences, cilt.36, sa.1, ss.21-26, 2024 (Scopus, TRDizin)

Özet

Objective: Cardiac syndrome X (CSX) is used to define patients with ischemic chest pain and normal coronary arteries, as revealed by angiography. The etiology of CSX may be associated with extensive coronary microvascular endothelial dysfunction, inflammation, and oxidative stress. We aimed to simultaneously investigate the relationships of serum vitamin D levels with oxidative stress, atherogenic index of plasma (AIP) and systemic inflammation marker C-reactive protein (CRP) to albumin ratio in CSX patients. Material and Methods: The present study group included 52 consecutive symptomatic patients diagnosed with CSX and 42 healthy controls. Serum total cholesterol, high-density lipoprotein (HDL), triglyceride, vitamin D, CRP, serum advanced oxidation protein product, and Ferric reducing ability of plasma levels were measured. The CRP/albumin ratio was determined. The AIP was calculated as log (triglyceride/HDL-C). Results: Patients with CSX had decreased vitamin D levels [11.2 (IQR: 6.3) ng/mL vs. 14.8 (IQR: 6.4) ng/mL; p=0.05] and higher CRP/albumin ratios [1.42 (0.84) vs. 1.01 (0.36); p=0.01] and similar AIP (0.11±0.30 vs. 0.14±0.29; p=0.76) compared to the control group. There was a weak negative correlation between vitamin D and CRP/albumin ratio (r=-0.23, p=0.03) levels. Conclusion: The reduction of vitamin D levels and systemic inflammation may play a role in the development of CSX.