Evaluation of oxidative stress in the spermatic and peripheral veins of patients with varicocele Vari̇koselli̇olgularda spermati̇k ve peri̇feri̇k vendek̇i oksi̇dati̇f stresi̇n deǧerlendi̇ṙilmeṡi
Turk Uroloji Dergisi, cilt.33, sa.1, ss.40-44, 2007 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 33 Sayı: 1
- Basım Tarihi: 2007
- Dergi Adı: Turk Uroloji Dergisi
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.40-44
- Anahtar Kelimeler: Infertility, Oxidative stress, Reactive oxygen species, Varicocele
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Introduction: It is suggested that oxidative stress has an important role in sperm dysfunction in patients with varicocele. The aim of this study was to determine the free oxygen radicals from peripheral and spermatic vein blood samples of the men with infertility or clinical varicocele before varicocelectomy. Materials and Methods: A total of 18 patients with varicocele were recruited in this study. Semen analyzes of patients were evaluated at least two times. Blood samples of 2 cc were drawn from the testicular side of the spermatic vein before ligation of varicocele veins. Synchronous blood samples were drawn from the corresponding peripheral vein as well. Superoxide dismutase (SOD), glutathione peroxidase and glutathione reductase levels were measured at spermatic and peripheral blood erythrocytes; malondialdehyde and total antioxidant capacity were measured. All patients were clinically evaluated in postoperative 1st and 3rd months, as well as control semen analyzes were done. Results: The mean age of patients was 24.5±4.2 (range:16-30 years) and the grade of varicoceles that was detected with physical examination was 2.2±0.6. At spermatic vein eryhtrocytes SOD, glutathione peroxidase and glutathione reductase levels were statistically lower than peripheral vein eryhtrocytes (p=0.012, p<0.0001 and p=0.006, respectively). Spermatic vein plasma malondialdehyde level was statistically higher than peripheral vein plasma (p<0.0001). Total antioxidant capacity was higher than the peripheral plasma (p=0.014). Conclusion: Oxidative stress is significantly higher in the spermatic vein of patients with varicocele. We think that oxidative stress is one of the factors that is involved in the varicocele associated sperm dysfunction.