Investigation of cholelitholytic and biologic effects of methyl tertiary butyl ether (MTBE) in dogs with implanted gallstones

Mas M., Ateskan O., Dinc A., Milli U., NALBANT S., ERDEM H., ...Daha Fazla

Turkish Journal of Gastroenterology, cilt.8, sa.4, ss.417-422, 1997 (Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 4
  • Basım Tarihi: 1997
  • Dergi Adı: Turkish Journal of Gastroenterology
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.417-422
  • Anahtar Kelimeler: Gallstone, Methyl tertiary butyl ether
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Recently, several nonsurgical approaches for treatment of gallstones have become more popular, especially for patients that are, considered high risk surgical candidates. One of these new techniques is gallstone dissolution with Methyl Tertiary Butyl Ether (MTBE). Although minimal anesthetic side effect have been noted vomiting and hemolysis due to MTBE have been reported. Tissue response of the biliary system, liver and duodenum have not been well-studied. In this study, we planned to determine the acute biological and biochemical effects on animal models before clinical application of MTBE. 7 mongrel dogs (one control, 6 with implanted gallstones) were studied. Gallstones of equal number and size were surgically implanted into the dogs and 5F catheters were sutured into the gall bladders. MTBE was infused 7-10 days postoperatively via the catheters in aliquots of 5-10 ml. Stone diameter was measured using serial ultrasonography and radioscopy. At necropsy, the dogs had fragmented and reduced sized gallstones and residual debris in their gall bladders. In some dogs, the gall bladders and common bile duct mucosas showed small hemorrhages. It was thought that nonspecific inflammatory changes of the gall bladders could have resulted from the surgical placement of the catheters and gallstones, or the MTBE. To conclude, in spite of poor clinical tolerance, mild to moderate tissue response in the biliary system and minor biochemical changes, MTBE is an excellent cholesterol - solubilizing agent.