Acrodermatitis dysmetabolica: Lessons from two pediatric cases


Kahraman A. B., Cosar M. S., Dogan E. E., ÜNLÜ Y., UĞUR C., BAĞCI Z.

Journal of Pediatric Endocrinology and Metabolism, cilt.38, sa.3, ss.299-304, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1515/jpem-2024-0542
  • Dergi Adı: Journal of Pediatric Endocrinology and Metabolism
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.299-304
  • Anahtar Kelimeler: acrodermatitis dysmetabolica, inherited metabolic disorders, maple syrup urine disease, nutritional deficiency, propionic acidemia
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Objectives: Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency. Case presentation: This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention. Conclusions: These cases emphasize the importance of identifying AD in IMDs and the critical need for meticulous monitoring of amino acid levels, as deficiencies may lead to severe complications.