The impact of vitamin B12 treatment on ejaculatory functions in men: Symptomatic relief and improved outcomes
Revista Internacional de Andrologia, cilt.24, ss.33-40, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24
- Basım Tarihi: 2026
- Doi Numarası: 10.22514/j.androl.2025.039
- Dergi Adı: Revista Internacional de Andrologia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, DIALNET
- Sayfa Sayıları: ss.33-40
- Anahtar Kelimeler: Premature ejaculation, Intravaginal ejaculatory latancy time, Premature ejaculation diagnostic tool, Vitamin B12, Premature ejaculation profile
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Background: To investigate whether intramuscular vitamin B12 treatment has an effect on ejaculaory functions in male patients with vitamin B12 deficiency. Methods: Male patients diagnosed with vitamin B12 deficiency in the internal medicine outpatient clinic of our hospital between October 2024 and March 2025 and started to receive intramuscular vitamin B12 treatment were included in study. The scores obtained from the self-estimated intravaginal ejaculation latency time (IELT), premature ejaculation diagnostic tool (PEDT), and premature ejaculation profile (PEP) questionnaires, reflecting the ejaculatory status of these patients before treatment, were recorded. After 3 months of treatment, these scores were re-recorded via phone calls, and scores recorded before and after treatment were compared. Results: The study included 54 patients. The mean age of the patients was 43.46 ± 13.3 years, the mean pretreatment IELT was 2.4 ± 1.4 min, and the mean pre-treatment PEDT score was 11.5 ± 4.6. In both the whole patient group and the premature ejaculation (PE) group, a statistically significant difference was observed in the items of perceived control over ejaculation, satisfaction with sexual intercourse, and interpersonal difficulty related to ejaculation from the PEP questionnaire forms completed after treatment, with no significant change found in the item of personal distress related to ejaculation. In terms of IELT and PEDT, no differences were observed in the whole patient group after treatment, whereas a statistically significant improvement was observed in the PE group. Conclusions : Intramuscular vitamin B12 may delay ejaculation times and improve sexual satisfaction levels in male patients based on the responses given by the patients to the questions in the survey forms. Clinical Trial Registration: The study was retrospectively registered with ClinicalTrials.gov as: NCT07036497.