Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery
Journal of Cardiovascular Pharmacology, cilt.25, sa.3, ss.508-510, 1995 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 3
- Basım Tarihi: 1995
- Doi Numarası: 10.1097/00005344-199503000-00025
- Dergi Adı: Journal of Cardiovascular Pharmacology
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.508-510
- Anahtar Kelimeler: VASCULAR 5-HT1, LIKE RECEPTORS, SUMATRIPTAN, AMPLIFICATION, PRECONTRACTION, RABBIT ILIAC ARTERY
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT1-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC10-EC20) of prostaglandin F2α, (PGF2α), angiotensin II (AII), histamine. norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT1like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study. © 1995 Raven Press, Ltd., New York.