Long-term follow-up of patients with adult-onset subacute sclerosing panencephalitis
Journal of the Neurological Sciences, cilt.275, sa.1-2, ss.113-116, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 275 Sayı: 1-2
- Basım Tarihi: 2008
- Doi Numarası: 10.1016/j.jns.2008.07.033
- Dergi Adı: Journal of the Neurological Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.113-116
- Anahtar Kelimeler: Subacute sclerosing panencephalitis, Adult-onset, Prognosis, Rubeola, Alpha-interferon, Isoprinosine
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Subacute sclerosing panencephalitis (SSPE) is a rare infectious central nervous system disease with a poor prognosis. Nineteen patients, 18 males and one female, ranging in age from 18 to 22, mean 19.6 ± 1.5 years with SSPE were evaluated. We treated 9 patients with oral isoprinosine and 10 patients with alpha-interferon plus oral isoprinosine and followed up for 16 to 160 months. Of the 9 patients treated with oral isoprinosine, 7 (77.7%) died, one stabilized, and one showed progression. Seven (70%) of 10 patients treated with alpha-interferon plus oral isoprinosine died, one showed progression, and stabilization was observed in two patients. Thus, we suggest that isoprinosine alone or in combination with intraventricular interferon did not change the prognosis in long-term follow-up periods. © 2008 Elsevier B.V. All rights reserved.