Can increased or decreased COX2 and P21 expression be used in illness monitoring of gastric cancer and its potential precursor lesions?

YEŞİLLİK S., Alömeroğlu M., Yildiz B., BAŞGÖZ B. B., GÜLŞEN M.

Gulhane Medical Journal, cilt.62, sa.3, ss.151-156, 2020 (Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/gulhane.galenos.2020.793
  • Dergi Adı: Gulhane Medical Journal
  • Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.151-156
  • Anahtar Kelimeler: Atrophic gastritis, Cyclooxygenase-2, Gastric cancer, Gastritis, Intestinal metaplasia, Protein P21
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Aims: Early diagnosis and treatment can improve the prognosis of patients with gastric cancer. Therefore, identification and follow-up of patients who are under the risk of gastric cancer can improve the success of treatment and quality of life. Methods: In our study, cyclooxygenase-2 (COX2) and P21 expressions of the patients with gastric adenocarcinoma and its precursor lesions atrophic gastritis and intestinal metaplasia were examined retrospectively with the immunohistochemical method. Results: Forty patients were enrolled in each group. Grade and intensity of COX2 expressions were high in all three groups in accordance with the literature. In contrast with COX2 expressions, the grade and intensity of P21 expressions were very low in all three groups. Expressions of P21 were not observed in the vast majority of the gastric cancer group. Due to slight expressions, we detected statistically significant differences in both grading and intensity of P21 expressions between precancerous lesions and gastric cancer. Conclusions: High COX2 expressions were consistent with literature. Decreased P21 expressions can reveal the relationship between loss of P21 expression and poor prognosis. Increased COX2, expression, especially in atrophic gastritis patients, and decreased P21 expression may be used in the follow-up of patients with gastric cancer and its precursor lesions.