Rethinking cancer evolution: from genetic mutations to complex information systems in tumor reversion
Evolution, Medicine and Public Health, cilt.13, sa.1, ss.1-4, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 13 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.1093/emph/eoae032
- Dergi Adı: Evolution, Medicine and Public Health
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
- Sayfa Sayıları: ss.1-4
- Anahtar Kelimeler: cancer, evolution, genetic, mutations, information systems
- Sağlık Bilimleri Üniversitesi Adresli: Evet
Özet
Cancer research has historically focused on the somatic mutation theory, viewing cancer as a consequence of genetic mutations. However, this perspective has limitations in explaining phenomena like tumor reversion and cancer heterogeneity. This paper introduces an alternative approach: viewing cancer as a complex information-processing system shaped by its microenvironment. By integrating historical data on tumor reversion and insights into evolutionary dynamics, I propose a reframing of cancer biology. This process-oriented perspective highlights the role of cellular plasticity and adaptive behaviors, offering new pathways for therapeutic development.