Olfactory Dysfunction: Its Association with Subjective Cognitive Impairment in Patients with Major Depression

Kaya E., Göker A. E.

Journal of Nervous and Mental Disease, cilt.210, sa.3, ss.172-178, 2022 (SCI-Expanded, SSCI, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 210 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1097/nmd.0000000000001435
  • Dergi Adı: Journal of Nervous and Mental Disease
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ATLA Religion Database, BIOSIS, CAB Abstracts, Child Development & Adolescent Studies, CINAHL, Educational research abstracts (ERA), EMBASE, MEDLINE, MLA - Modern Language Association Database, Psycinfo, Violence & Abuse Abstracts
  • Sayfa Sayıları: ss.172-178
  • Anahtar Kelimeler: Olfactory dysfunction, major depression, subjective cognitive impairment, olfactory threshold
  • Sağlık Bilimleri Üniversitesi Adresli: Evet

Özet

Olfactory disorders may be observed together with cognitive impairment in patients with major depressive disorder (MDD). This study compared olfactory performances between patients with MDD and healthy controls and investigated the relationship between olfactory performance and subjective cognitive impairment in these patients. This study included 52 patients diagnosed with MDD and 46 healthy controls. The participants were evaluated in terms of their olfactory capacities (threshold, discrimination, and identification), subjective cognitive impairment, and depression. Although the olfactory threshold (OT) and olfactory discrimination scores were lower in patients with MDD compared with those in the control group, their olfactory identification scores did not differ significantly. OT was negatively correlated with subjective cognitive impairment and may serve as a determinant for subjective cognitive changes. Consequently, patients with MDD had lower olfactory performances compared with healthy controls. Finally, OT may be a component of subjective cognitive impairment in MDD.